Journals (undergraduate co-authors are denoted by asterisk)

Smith, M.A., Pennock, M.M.*, Walker, K.L.* & Lang, K.C. (in press). Access to a running wheel decreases drug-primed and cue-induced reinstatement in male and female rats. Drug and Alcohol Dependence.

Smith, M.A., Walker, K.L.*, Cole, K.T.* & Lang, K.C. (in press). The Effects of Aerobic Exercise on Cocaine Self-Administration in Male and Female Rats. Psychopharmacology.

Smith, M.A. & Pitts E.G.* (2011). Access to a running wheel inhibits the acquisition of cocaine self-administration. Pharmacology, Biochemistry and Behavior, 100, 237-243.

Smith, M.A., Greene-Naples, J.L.*, Felder, J.N.*, Iordanou, J.C.*, Lyle, M.A.* & Walker, K.L.* (2009). The effects of repeated opioid administration on locomotor activity: I. Opposing action of mu and kappa receptors. Journal of Pharmacology and Experimental Therapeutics, 330, 468-475.

Smith, M.A., Greene-Naples, J.L.*, Lyle, M.A.*, Iordanou, J.C.* & Felder, J.N.* (2009). The effects of repeated opioid administration on locomotor activity: II. Unidirectional cross-sensitization to cocaine. Journal of Pharmacology and Experimental Therapeutics, 330, 476-486.

Smith, M.A., Iordanou, J.C.*, Cohen, M.B.*, Cole, K.T.*, Gergans, S.R.*, Lyle, M.A.* & Schmidt, K.T.* (2009). Effects of environmental enrichment on sensitivity to cocaine in female rats: Importance of control rates of behavior. Behavioural Pharmacology, 20, 312-321.

Smith, M. A., Schmidt, K. T.*, Iordanou, J. C.* & Mustroph, M. L.* (2008). Aerobic exercise decreases the positive reinforcing effects of cocaine. Drug and Alcohol Dependence, 98, 129-135.

Smith, M. A., Cole, K. T.*, Gergans, S. R.*, Iordanou, J. C.*, Lyle, M. A.* & Schmidt, K. T.* (2008). Effects of environmental enrichment on sensitivity to mu, kappa, and mixed-action opioids in female rats. Physiology and Behavior, 94, 563-568.

Smith, M. A., Gergans, S. R.*, Iordanou, J. C.* & Lyle, M. A.* (2008). Exercise increases sensitivity to the conditioned rewarding effects of cocaine. Pharmacological Reports, 60, 561-565.

Smith, M. A., Ward, S. J. & Roberts, D. C. S. (2008). Lesions of the dorsomedial frontal cortex block sensitization to the reinforcing effects of cocaine. Pharmacology, Biochemistry and Behavior, 88, 238-246.

Smith, M. A., Gergans, S. R.* & Lyle, M. A.* (2006). The motor-impairing effects of GABAA and GABAB agonists in γ-hydroxybutyrate (GHB) -treated rats: Cross-tolerance to baclofen but not flunitrazepam. European Journal of Pharmacology, 552, 83-89.

Smith, M. A. & Lyle, M. A.*(2006). Chronic exercise decreases sensitivity to mu opioids in female rats: Correlation with exercise output. Pharmacology, Biochemistry and Behavior, 85, 12-22.

Smith, M. A., Chisholm, K. A.*, Bryant, P. A.*, Greene, J. L.*, McClean, J. M.*, Stoops, W. W.* & Yancey, D. L.* (2004). Social and environmental influences on sensitivity to mu opioid in rats: Importance of an opioid's relative efficacy at the mu receptor. Psychopharmacology, 181, 27-37.

Morgan, D., Smith, M. A. & Roberts, D. C. S. (2005) Binge self-administration and deprivation produces sensitization to the reinforcing effects of cocaine in rats. Psychopharmacology, 178, 309-316.

Smith, M. A., Craig, C. K.* & French, A. M.* (2004). Agonist and antagonist effects of benzodiazepines on motor performance: Influence of relative intrinsic efficacy and task difficulty. Behavioural Pharmacology, 15, 215-223.

Smith, M. A., Yancey, D. L.*, Morgan, D., Liu, Y., Froestl, W., & Roberts, D. C. S. (2004). Effects of positive allosteric modulators of the GABAB receptor on cocaine self-administration. Psychopharmacology, 173, 105-111., 173, 105-111.

Smith, M. A., McClean, J. M.* & Bryant, P. A.* (2004). Sensitivity to the effects of a kappa opioid in rats with free access to exercise wheels: Differential effects across behavioral measures. Pharmacology, Biochemistry and Behavior, 77, 49-57.

Smith, M. A., McClean, J. M.* & Greene, J. L.* (2003). Enhanced sensitivity to the antinociceptive effects of kappa opioids in naltrexone-treated rats: Dose and time-dependent effects. Behavioural Pharmacology, 14, 641-647.

Smith, M. A., Bryant, P. A.* & McClean, J. M.* (2003). Environmental enrichment enhances sensitivity to the effects of kappa opioids: Studies on antinociception, diuresis and conditioned place preference. Pharmacology, Biochemistry and Behavior, 76, 93-101.

Smith, M. A. & Yancey, D. L.* (2003). Sensitivity to the effects of opioids in rats with free access to exercise wheels: Mu opioid tolerance and physical dependence. Psychopharmacology, 167, 426-434.

Smith, M. A., Gordon, K. A.*, Craig, C. K.*, Bryant, P. A.*, Ferguson, M. E.*, French, A. M.*, Gray, J. D.*, McClean, J. M.* & Tetirick, J. C.* (2003). Interactions between opioids and cocaine on locomotor activity: Influence of an opioid's relative efficacy at the mu receptor. Psychopharmacology, 167, 265-273.

Smith, M. A. & French, A. M.* (2002). Age-related differences in sensitivity to the antinociceptive effects of kappa opioids in adult male rats. Psychopharmacology, 166, 255-264.

Smith, M. A. & Gray, J. D.* (2001). Age-related differences in sensitivity to the antinociceptive effects of opioids in male rats: Influence of nociceptive intensity and intrinsic efficacy at the mu receptor. Psychopharmacology, 156, 445-453.

Smith, M. A. & Stoops, W. W.* (2001). Sensitivity to the effects of sedative-hypnotics on motor performance: Influence of task difficulty and chronic phenobarbital administration. Behavioural Pharmacology, 12, 125-134.

Smith, M. A., Barrett, A. C.* & Picker, M. J. (1999). Antinociceptive effects of opioids following acute and chronic administration of butorphanol: Influence of stimulus intensity and relative efficacy at the mu receptor. Psychopharmacology, 143, 261-269.

Morgan, D., Cook, C. D., Smith, M. A. & Picker, M. J. (1999). Interaction between the antinociceptive effects of partial opioid agonists and morphine: Influence of nociceptive stimulus intensity. Anesthesia and Analgesia, 88, 407-413.

Smith, M. A. & Picker, M. J. (1998). Tolerance and cross tolerance to the rate-suppressing effects of opioids in butorphanol-treated rats: Influence of maintenance dose and relative efficacy at the mu receptor. Psychopharmacology, 140, 57-68.

Smith, M. A., Pitts, R. A. & Picker, M. J. (1997). Tolerance and cross tolerance to the accuracy- and rate-decreasing effects of mu opioids in rats responding under a fixed-consecutive-number schedule. Drug and Alcohol Dependence, 46, 19-30.

Picker, M. J., Benyas, S.*, Horowitz, J. A.*, Thompson, K.*, Mathewson, C. & Smith, M. A. (1997). Discriminative stimulus effects of butorphanol: Influence of training dose on the substitution patterns produced by mu, kappa and delta opioids. Journal of Pharmacology and Experimental Therapeutics, 279, 1130-1141.

Smith, M. A. & Picker, M. J. (1995). Examination of the kappa agonist and antagonist properties of opioids in the rat drug discrimination procedure: Influence of training dose and intrinsic efficacy. Behavioural Pharmacology, 6, 703-717.

Picker, M. J., Smith, M. A. & Morgan, D. (1994). Assessment of the relative intrinsic efficacy of profadol and meperidine in a pigeon drug discrimination procedure: Relevance to partial substitution patterns. Behavioural Pharmacology, 5, 61-70.

Picker, M. J., Yarbrough, J., Hughes, C. E., Smith, M. A., Morgan, D. & Dykstra, L. A. (1993). Agonist and antagonist effects of intermediate efficacy mu opioids in the pigeon drug discrimination procedure: Influence of training dose and individual responsiveness. Journal of Pharmacology and Experimental Therapeutics, 266, 756-767.

Published Abstracts & Presentations (undergraduate co-authors are denoted by asterisk)

Smith, M.A., Pennock, M.M.*, Pitts, E.G.*, Walker, K.L.* & Lang K.C. (2011). The effects of amphetamine, butorphanol, and their combination on cocaine self-administration. (presented at the 14th biennial meeting of the European Behavioural Pharmacology Society in Amsterdam, the Netherlands)

Smith, M.A. (2011). Peer influences on drug self-administration: Social facilitation and social inhibition of cocaine intake. (presented at the 40th annual meeting of the International Study Group Investigating Drugs as Reinforcers in Hollywood, FL)

Smith, M.A. & Pitts, E.G.* (2011). Aerobic exercise decreases the acquisition of cocaine self-administration. (presented at the 73rd annual meeting of the College on Problems of Drug Dependence in Hollywood, FL)

Smith, M.A., Kerns, D.C.*, Newsom, P.C.* & Schmidt, K.T.* (2010). Ultra-low doses of naltrexone do not alter the locomotor or positive-reinforcing effects of cocaine. Society for Neuroscience Abstracts, 36, 574.11. (presented at the 40th annual meeting of the Society for Neuroscience in San Diego, CA)

Lang, K.C. & Smith, M.A. (2010). Aerobic exercise decreases binge-like patterns of excessive cocaine intake under unlimited access conditions. Society for Neuroscience Abstracts, 36, 574.12. (presented at the 40th annual meeting of the Society for Neuroscience in San Diego, CA)

Smith, M.A., Pennock, M.M.* & Walker, K.L.* (2010). Effects of aerobic exercise on reinstatement of cocaine-seeking behavior. (presented at the 72nd annual meeting of the College on Problems of Drug Dependence in Scottsdale, AZ)

Smith, M.A., Walker, K.L.* & Cole, K.T.* (2009). Aerobic exercise attenuates the escalation of cocaine intake under extended-access conditions. (presented at the 71st annual meeting of the College on Problems of Drug Dependence in Reno, NV)

Smith, M.A. & Roberts, D. C.,S. (2008). The adenosine A2A receptor agonist CGS 21680 decreases the positive-reinforcing effects of cocaine. Society for Neuroscience Abstracts, 34, 359.2. (presented at the 38th annual Society for Neuroscience meeting in Washington, DC)

Smith, M. A. & Roberts, D. C. S. (2008). Cocaine self-administration and wheel-running in rats responding in a discrete-trials procedure. (presented at the 116th annual meeting of the American Psychological Association in Boston, MA)

Smith, M. A., Schmidt, K. T.*, Iordanou, J. C.* & Mustroph, M. L.* (2008). Chronic exercise decreases the reinforcing efficacy of cocaine. (presented at the 70th annual meeting of the College on Problems of Drug Dependence in San Juan, PR)

Smith, M. A., Coles, K. T.*, Gergans, S. R.*, Iordanou, J. C.*, Lyle, M. A.* & Schmidt, K. T.* (2007). Effects of environmental enrichment on sensitivity to opioid receptor agonists in female rats. Society for Neuroscience Abstracts, 33, 387.8. (presented at the 37th annual Society for Neuroscience meeting in San Diego, CA)

Smith, M. A. & Iordanou, J. C.* (2007). The effects of social and environmental enrichment on cocaine self-administration in female rats. (presented at the 69th annual meeting of the College on Problems of Drug Dependence in Quebec City, Quebec)

Smith, M. A., Gergans, S. R.* & Lyle, M. A.* (2006). The motor-impairing effects of GHB, flunitrazepam, and baclofen in GHB-treated rats. Society for Neuroscience Abstracts, 32:768.21. (presented at the 36th annual Society for Neuroscience meeting in Atlanta, GA)

Smith, M. A., Gergans, S. R.*, Iordanou, J. C.* & Lyle, M. A.* (2006). The effects of aerobic exercise on sensitivity to cocaine. (presented at the 68th annual meeting of the College on Problems of Drug Dependence in Scottsdale, AZ)

Mah, N. A.*, Feor, R., Penev, T., Molinek, D., Muchane, M., Tonidandel, S., Smith, M. A. & Ramirez, J. J. (2005). The neuron connection 3: Modeling Parkinson's disease. Society for Neuroscience Abstracts, 31, 20.8. (presented at the 35th annual meeting of the Society for Neuroscience in Washington, DC)

Smith, M. A., Cohen, M. B.*, Gergans, S. R.*, Iordanou, J. C.* & Lyle, M. A.* (2005). Social and environmental enrichment enhances sensitivity to cocaine in female rats. Society for Neuroscience Abstracts, 31, 452.3. (presented at the 35th annual meeting of the Society for Neuroscience in Washington, DC)

Smith, M. A. & Lyle, M. A.* (2005). Chronic exercise decreases sensitivity to mu opioids in female rats: Correlation with exercise output. (presented at the 67th annual meeting of the College on Problems of Drug Dependence in Orlando, FL)

Smith, M. A. & Roberts, D. C. S. (2004). Lesions of the dorsal prefrontal cortex block cocaine sensitization. (presented at the 112th annual meeting of the American Psychological Association in Honolulu, HI)

Smith, M. A. & Greene, J. L.* (2004). Cross sensitization between opioids and cocaine. (presented at the 66th annual meeting of the College on Problems of Drug Dependence in San Juan, PR)

Smith, M. A., Bryant, P. A.* & McClean, J. M.* (2003). Environmental enrichment enhances sensitivity to kappa opioids. (presented at the 65th annual meeting of the College on Problems of Drug Dependence in Bal Harbour, FL)

Morgan, D., Mateo, Y., Collins, A. J., Yancey, D. L., Childers, S. R., McCracken, C., Smith, M. A., Jones, S. R. & Roberts, D. C. S. (2003). Neurobiological alterations associated with changes in the reinforcing efficacy of cocaine. (presented at the 65th annual meeting of the College on Problems of Drug Dependence in Bal Harbour, FL)

Smith, M. A., Yancey, D. L., Morgan, D., Liu, Y., Froestl, W. & Roberts, D. C. S. (2003). Positive allosteric modulators of the GABAB receptor decrease cocaine self-administration. Society for Neuroscience Abstracts, 29, 424.16. (presented at the 33rd annual meeting of the Society for Neuroscience in New Orleans, LA)

Smith, M. A. & McClean, J. M.* (2002). Chronic naltrexone treatment enhances sensitivity to the antinociceptive effects of kappa opioids. Society for Neuroscience Abstracts, 28, 783.8. (presented at the 32nd annual meeting of the Society for Neuroscience in Orlando, FL)

Smith, M. A., Gordon, K. A.*, Craig, C. K.*, Ferguson, M. E.*, French, A. M.*, Gray, J. K.* & McClean, J. M.* (2002). Drug interactions between cocaine and mixed-action opioids on locomotor activity. Drug and Alcohol Dependence, 66 Suppl 1, 166. (presented at the 64th annual meeting of College on the Problems of Drug Dependence in Quebec City, Quebec)

Smith, M. A. & Yancey, D. L.* (2001). Chronic exercise increases nociceptive threshold but reduces sensitivity to the effects of mu opioids. Society for Neuroscience Abstracts, 27, 960.14. (presented at the 31st annual meeting of the Society for Neuroscience in San Diego, CA)

Smith, M. A. & French, A. M.* (2001). Young and aged rats differ in sensitivity to the antinociceptive effects of kappa opioids. Drug and Alcohol Dependence, 63 Suppl 1, 148. (presented at the 63rd annual meeting of the College on Problems of Drug Dependence in Scottsdale, AZ)

Smith, M. A., Chisholm, K. A.*, Stoops, W. W.* & Lawson, V. C. (2000). Environmental enrichment enhances sensitivity to the antinociceptive effects of mu opioids. Society for Neuroscience Abstracts, 26, 282. (presented at the 30th annual meeting of the Society for Neuroscience in New Orleans, LA)

Smith, M. A., Stoops, W. W.* & Morgan, D. (2000). Sensitivity to the effects of CNS depressants on motor performance in phenobarbital-treated rats. Drug and Alcohol Dependence, 60 Suppl 1, 207. (presented at the 62nd annual meeting of the College on Problems of Drug Dependence in San Juan, PR)

Smith, M. A. & Gray, J. D.* (1999). Young and aged rats differ in sensitivity to the antinociceptive effects of mu opioids. Behavioral Pharmacology, 10 Suppl 1. (presented at the 43rd annual meeting of the Behavioral Pharmacology Society in Boston, MA)

Smith ,M. A., Barrett, A. C.* & Picker, M. J. (1998). Tolerance to the antinociceptive effects of mu opioids in butorphanol-treated rats. NIDA Research Monograph, 179, 231. (presented at the 60th annual meeting of the College on Problems of Drug Dependence in Scottsdale, AZ)

Smith, M. A., Walker, E. A. & Picker, M. J. (1997). Changes in potency of mu and kappa opioids following chronic administration of butorphanol. Society for Neuroscience Abstracts, 23, 986. (presented at the 27th annual meeting of the Society for Neuroscience in New Orleans, LA)

Smith, M. A. & Picker, M. J. (1997). Discriminative stimulus properties of the partial mu agonist dezocine. NIDA Research Monograph, 178, 169. (presented at the 59th annual meeting of the College on Problems of Drug Dependence in San Juan, PR)

Picker, M. J., Cook, C. D., Morgan, D. & Smith, M. A. (1997). Drug discrimination in pigeons successively trained to discriminate the mu opioid butorphanol and the kappa opioid bremazocine. NIDA Research Monograph, 178, 169. (presented at the 59th annual meeting of the College on Problems of Drug Dependence in San Juan, PR)

Smith, M. A. & Picker, M. J. (1996). Development of tolerance and cross tolerance to the effects of opioids in butorphanol-treated rats. NIDA Research Monograph, 174, 168. (presented at the 58th annual meeting of the College on Problems of Drug Dependence in Nashville, TN)

Morgan, D., Smith, M. A., Cook, C. D. & Picker, M. J. (1996). Effects of levorphanol, buprenorphine and butorphanol alone and in combination with morphine in a rat tail withdrawal procedure. NIDA Research Monograph, 174, 161. (presented at the 58th annual meeting of the College on Problems of Drug Dependence in Nashville, TN)

Smith, M. A., Benyas, S.*, Thompson, K.*, Horowitz, J. A.* & Picker, M. J. (1995). Discriminative stimulus effects of butorphanol: Involvement of mu, kappa and delta opioid receptor activity. NIDA Research Monograph, 162, 339. (presented at the 57th annual meeting of the College on Problems of Drug Dependence in Scottsdale, AZ)

Smith, M. A., Pitts, R. C., Dykstra, L. A. & Picker, M. J. (1994). Effects of opioids with varying degrees of intrinsic efficacy at the mu receptor on fixed-consecutive number responding in rats. Society for Neuroscience Abstracts, 20, 227. (presented at the 24th annual meeting of the Society for Neuroscience in Miami Beach, FL)

Smith, M. A. & Picker, M. J. (1994). Characterization of the discriminative stimulus effects of kappa opioids and mixed action opioids: Role of training dose and intrinsic efficacy. NIDA Research Monograph, 153, 92. (presented at the 56th annual meeting of the College on Problems of Drug Dependence in West Palm Beach, FL)

Smith, M. A., Morgan, D., Hughes, C. E., Dykstra, L. A. & Picker, M. J. (1993). Stimulus effects of mixed action opioids: Interactions of training dose, intrinsic efficacy and inter-animal differences. NIDA Research Monograph, 141, 276. (presented at the 55th annual meeting of the College on Problems of Drug Dependence in Toronto, Ontario)

Morgan, D., Smith, M. A. & Picker, M. J. (1993). Stimulus effects of profadol and meperidine: Interaction with fentanyl and butorphanol. NIDA Research Monograph, 141, 275. (presented at the 55th annual meeting of the College on Problems of Drug Dependence in Toronto, Ontario)